3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide

Base Information

• Chemical Name: 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide
• CAS No.: 438193-58-9
• Molecular Formula: C₁₈H₁₇BrN₂O₂
• Molecular Weight: 373.249
• Mol file: 438193-58-9.mol

Synonyms:3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide

Chemical Property of 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide

Chemical Property:

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Technology Process of 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide

There total 1 articles about 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-tolyl iodide (624-31-7) + 3-bromo-2-(4-methoxybenzyl)pyrazole 1-oxide (384339-31-5) → 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide (438193-58-9)

Guidance literature:

3-bromo-2-(4-methoxybenzyl)pyrazole 1-oxide; With lithium diisopropyl amide; In tetrahydrofuran; at -100 ℃;

With zinc(II) chloride; In tetrahydrofuran; at -100 ℃;

4-tolyl iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; Further stages.;

DOI:10.1021/jo015997i

Reference yield: 77.0%

o-cyanobromobenzene (2042-37-7) + 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide (438193-58-9) → 3-(2-cyanophenyl)-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole-1-oxide

Guidance literature:

3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.25h;

With zinc(II) chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.75h;

o-cyanobromobenzene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 10h; Further stages.;

DOI:10.1021/jo015997i

Reference yield: 70.0%

2-nitro-benzaldehyde (552-89-6) + 3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide (438193-58-9) → 3-(2-formylphenyl)-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole-1-oxide

Guidance literature:

3-bromo-2-(4-methoxybenzyl)-5-(4-methylphenyl)pyrazole 1-oxide; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.25h;

With zinc(II) chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.75h;

2-nitro-benzaldehyde; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 10h; Further stages.;

DOI:10.1021/jo015997i

upstream raw materials:

4-tolyl iodide

3-bromo-2-(4-methoxybenzyl)pyrazole 1-oxide