3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester

Base Information

• Chemical Name: 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester
• CAS No.: 440369-60-8
• Molecular Formula: C₃₆H₅₆O₈
• Molecular Weight: 616.836
• Mol file: 440369-60-8.mol

Synonyms:3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester

Chemical Property of 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester

There total 1 articles about 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

menthoxyacetic acid (40248-63-3) + benzyl 2,2-bis(hydroxylmethyl)propionate (179388-73-9) → 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester (440369-60-8)

Guidance literature:

With dicyclohexyl-carbodiimide; 4-(dimethylamino)pyridinium tosylate; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jo0200116

Reference yield: 97.0%

3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester (440369-60-8) → 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid (440369-63-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 18h;

DOI:10.1021/jo0200116

Reference yield:

3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid benzyl ester (440369-60-8) → 3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid 6-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-pyridin-2-ylmethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / H₂ / Pd/C / ethyl acetate / 18 h

2: 16 percent / 4-(dimethylamino)pyridinium p-toluenesulfonate; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h / 20 °C

With hydrogen; dicyclohexyl-carbodiimide; 4-(dimethylamino)pyridinium tosylate; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1021/jo0200116

upstream raw materials:

menthoxyacetic acid

benzyl 2,2-bis(hydroxylmethyl)propionate

Downstream raw materials:

3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-2-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxymethyl]-2-methyl-propionic acid