(S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

Base Information

Chemical Name:(S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide
CAS No.:862839-12-1
Molecular Formula:C₁₉H₂₆BrN₃O₃
Molecular Weight:424.338
Hs Code.:

Synonyms:(S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

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Technology Process of (S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

There total 4 articles about (S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (S)-2-Amino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

: 814-68-6,25189-84-8
acryloyl chloride

: 862839-12-1
(S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2005.05.115

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 862839-12-1
(S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: isobutyl chloroformate; Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

1.2: Et₃N / CH₂Cl₂ / 20 °C

2.1: LiOH / H₂O; methanol / 2 h / 20 °C

3.1: isobutyl chloroformate; Et₃N

4.1: CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

5.1: 50 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

With lithium hydroxide; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In methanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2005.05.115

Reference yield:

: 28635-99-6
(2S)-((2'S)-tert-butoxycarbonylamino-4-methylpentanoylamino)propionic acid

: 862839-12-1
(S)-2-Acryloylamino-4-methyl-pentanoic acid [(S)-1-(3-bromo-benzylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: isobutyl chloroformate; Et₃N

2: CF₃COOH / CH₂Cl₂ / 2 h / 20 °C

3: 50 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

With triethylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;
DOI:10.1016/j.tetlet.2005.05.115