(4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione

Base Information

• Chemical Name: (4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione
• CAS No.: 1160107-42-5
• Molecular Formula: C₁₆H₁₆N₄O₃
• Molecular Weight: 312.328
• Mol file: 1160107-42-5.mol

Synonyms:(4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione

Chemical Property of (4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione

There total 1 articles about (4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(4R,10aS)-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione (1160107-36-7) → (4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione (1160107-42-5)

Guidance literature:

(4R,10aS)-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione; With bromine; In tetrachloromethane; for 2h; Inert atmosphere; Reflux;

With sodium azide; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 7h;

DOI:10.1021/jo900679c

Reference yield: 67.0%

di-tert-butyl dicarbonate (24424-99-5) + (4R,10aS)-7-azido-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione (1160107-42-5) → (4R,10aS)-7-(tert-butoxycarbonylamino)-10a-methyl-4-phenyl-3,4,10,10atetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione (1160107-43-6)

Guidance literature:

With palladium dihydroxide; hydrogen; In methanol; for 0.0833333h; under 760.051 Torr;

DOI:10.1021/jo900679c

upstream raw materials:

(4R,10aS)-10a-methyl-4-phenyl-3,4,10,10a-tetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione

Downstream raw materials:

(4R,10aS)-7-(tert-butoxycarbonylamino)-10a-methyl-4-phenyl-3,4,10,10atetrahydro-1H-[1,4]oxazino[4,3-a]azepine-1,6(9H)-dione