tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate
• CAS No.: 1067658-81-4
• Molecular Formula: C₂₀H₂₉N₃O₄
• Molecular Weight: 375.468
• Mol file: 1067658-81-4.mol

Synonyms:tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property of tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate

There total 1 articles about tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-N-methyl-D-phenylalanine (37553-65-4,64263-83-8,85466-66-6) + (3S)-3-aminopiperidin-2-one hydrochloride (42538-31-8,406216-02-2) → tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate (1067658-81-4)

Guidance literature:

N-tert-butoxycarbonyl-N-methyl-D-phenylalanine; (3S)-3-aminopiperidin-2-one hydrochloride; With 2,3,5-trimethyl-pyridine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol801842v

Reference yield: 73.0%

tert-butyl methyl((S)-piperid-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate (1067658-81-4) → N-(S)-piperid-2-one-3-yl-(R)-2-methylamino-3-phenylpropanamide (1067658-87-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 7h; Cooling with ice;

DOI:10.1021/ol801842v

upstream raw materials:

N-tert-butoxycarbonyl-N-methyl-D-phenylalanine

(3S)-3-aminopiperidin-2-one hydrochloride

Downstream raw materials:

N-(S)-piperid-2-one-3-yl-(R)-2-methylamino-3-phenylpropanamide