(R)-2-BENZYL-3-HYDROXYPROPANOIC ACID

Base Information

• Chemical Name: (R)-2-BENZYL-3-HYDROXYPROPANOIC ACID
• CAS No.: 123802-80-2
• Molecular Formula: C10H12 O3
• Molecular Weight: 180.203
• Mol file: 123802-80-2.mol

Synonyms:Benzenepropanoicacid, a-(hydroxymethyl)-, (R)-;(R)-2-Benzyl-3-hydroxypropionic acid; (R)-2-Hydroxymethyl-3-phenylpropionicacid

Chemical Property of (R)-2-BENZYL-3-HYDROXYPROPANOIC ACID

Chemical Property:

• Melting Point: 67.5-68.5℃ (ethyl ether hexane )
• Boiling Point: 352.5±30.0 °C(Predicted)
• PKA: 4.22±0.10(Predicted)
• PSA: 57.53000
• Density: 1.219±0.06 g/cm3(Predicted)
• LogP: 0.92220

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-Benzyl-3-hydroxypropionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-BENZYL-3-HYDROXYPROPANOIC ACID

There total 30 articles about (R)-2-BENZYL-3-HYDROXYPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-2-(Hydroxymethyl)-3-phenyl-2-propenoic acid (131202-40-9) → (R)-2-hydroxymethyl-3-phenylpropionic acid (123802-80-2)

Guidance literature:

With (Sa)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₄)][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; triethylamine; In methanol; at 45 ℃; for 12h; under 4560.31 Torr; enantioselective reaction; Inert atmosphere; Schlenk technique; Autoclave;

DOI:10.1002/cjoc.201400361

Reference yield: 98.0%

(S)-3-((R)-2-Benzyloxymethyl-3-phenyl-propionyl)-4-isopropyl-oxazolidin-2-one (129779-05-1) → (R)-2-hydroxymethyl-3-phenylpropionic acid (123802-80-2)

Guidance literature:

With lithium hydroperoxide;

Reference yield: 46.5%

(RS)-2-hydroxymethyl-3-phenylpropionic acid (6811-98-9) → (R)-2-hydroxymethyl-3-phenylpropionic acid (123802-80-2)

Guidance literature:

With (1S,2R)-1-amino-2-indanol; In methanol; Reflux;

upstream raw materials:

(R)-2-(acetoxymethyl)-3-phenylpropanoic acid

(S)-3-((R)-2-Benzyloxymethyl-3-phenyl-propionyl)-4-isopropyl-oxazolidin-2-one

2R-benzyl-3-benzyloxypropanoic acid

2-benzyl-3-hydroxypropionic acid methyl ester

Downstream raw materials:

(S)-2-acetylthiomethyl-3-phenylpropanoic acid

(R)-2-(Benzyloxyamino-methyl)-3-phenyl-propionic acid

(3R)-N-benzyloxy-3-benzyl-2-azetidinone

(R)-2-[(Formyl-hydroxy-amino)-methyl]-N-((S)-1-hydroxy-2-oxo-azepan-3-yl)-3-phenyl-propionamide