(1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Base Information

Chemical Name:(1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane
CAS No.:408348-37-8
Molecular Formula:C₂₆H₂₄N₂O
Molecular Weight:380.489
Hs Code.:

Synonyms:(1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Chemical Property:

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Technology Process of (1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

There total 3 articles about (1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 408348-35-6
(1S,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

: 408348-37-8
(1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jo010852x

Reference yield:

: 76-83-5
trityl chloride

: 408348-37-8
(1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.87 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo010852x

Reference yield:

: 4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropyl]-1H-imidazole

: 408348-37-8
(1S,2R)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.87 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo010852x