4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

Base Information

Chemical Name:4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran
CAS No.:133739-87-4
Molecular Formula:C₂₂H₂₂FNO₄
Molecular Weight:383.419
Hs Code.:

Synonyms:4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

Suppliers and Price of 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

There total 2 articles about 4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 131610-09-8
1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethylbromide

: 130723-23-8
4-(3-hydroxy-5-fluorophenyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran

: 133739-87-4
4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00027a014

Reference yield:

: 130723-10-3
4-(3-Benzyloxy-5-fluorophenyl)-4-hydroxytetrahydropyran

: 133739-87-4
4-[3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)-5-fluorophenyl]-4-hydroxytetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 2585.7 Torr

2: 34 percent / K₂CO₃ / dimethylformamide / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00027a014