Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

Base Information

Chemical Name:Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester
CAS No.:263894-29-7
Molecular Formula:C₂₄H₂₂O₄
Molecular Weight:374.436
Hs Code.:

Synonyms:Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

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Chemical Property of Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

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Technology Process of Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

There total 2 articles about Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 879-18-5
naphthalene-1-carbonic acid chloride

: 321658-34-8
(S)-Hydroxy-(1-methyl-cyclopropyl)-acetic acid benzyl ester

: 263894-29-7
Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(99)00663-0

Reference yield:

: 157087-28-0
(S)-benzyl 2-hydroxy-3-methylbut-3-enoate

: 263894-29-7
Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Et₂Zn / CH₂Cl₂

2: 91 percent / Et₃N; DMAP / CH₂Cl₂

With dmap; diethylzinc; triethylamine; In dichloromethane; 1: cyclopropanation / 2: Condensation;
DOI:10.1016/S0960-894X(99)00663-0

Reference yield:

: 263894-29-7
Naphthalene-1-carboxylic acid (S)-benzyloxycarbonyl-(1-methyl-cyclopropyl)-methyl ester

: 263894-30-0
Naphthalene-1-carboxylic acid (S)-(4-methoxy-benzylcarbamoyl)-(1-methyl-cyclopropyl)-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: Et₃N; HOBt; PyBOP / dimethylformamide

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Condensation;
DOI:10.1016/S0960-894X(99)00663-0