(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Base Information

Chemical Name:(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride
CAS No.:1363153-79-0
Molecular Formula:C₃₆H₄₇BrFN₇O₅*ClH
Molecular Weight:793.176
Hs Code.:

(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Synonyms:(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

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Chemical Property of (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

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Technology Process of (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

There total 15 articles about (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363150-67-7
C₄₁H₅₅BrFN₇O₇

: 1363153-79-0
(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 10h;

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 1363153-79-0
(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Guidance literature:: Multi-step reaction with 14 steps

1.1: oxalyl dichloride / toluene / 2 h / Reflux

1.2: 2 h

2.1: acetic acid / 0.17 h / 90 °C

2.2: 1 h / Reflux

3.1: 1,4-dioxane / 12 h / Reflux

3.2: 3 h / Reflux

4.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

5.1: isopropyl alcohol / 2 h / Reflux

6.1: trifluoroacetic acid / 2 h / Heating

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

8.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; hexane / 10 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 20 °C

10.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

12.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

13.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

14.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

With hydrogenchloride; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 2426-84-8
4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde

: 1363153-79-0
(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Guidance literature:: Multi-step reaction with 15 steps

1.1: potassium permanganate / acetone / 2 h / 30 - 50 °C

2.1: oxalyl dichloride / toluene / 2 h / Reflux

2.2: 2 h

3.1: acetic acid / 0.17 h / 90 °C

3.2: 1 h / Reflux

4.1: 1,4-dioxane / 12 h / Reflux

4.2: 3 h / Reflux

5.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

6.1: isopropyl alcohol / 2 h / Reflux

7.1: trifluoroacetic acid / 2 h / Heating

8.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

9.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; hexane / 10 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 20 °C

11.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

12.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

13.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

14.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

15.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; ethyl acetate; isopropyl alcohol; acetone; toluene;