(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Base Information

• Chemical Name: (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride
• CAS No.: 1363153-79-0
• Molecular Formula: C₃₆H₄₇BrFN₇O₅*ClH
• Molecular Weight: 793.176
• Mol file: 1363153-79-0.mol

Synonyms:(S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Chemical Property of (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride

There total 15 articles about (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H55BrFN7O7 (1363150-67-7) → (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride (1363153-79-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 10h;

Reference yield:

4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid (60547-92-4) → (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride (1363153-79-0)

Guidance literature:

Multi-step reaction with 14 steps

1.1: oxalyl dichloride / toluene / 2 h / Reflux

1.2: 2 h

2.1: acetic acid / 0.17 h / 90 °C

2.2: 1 h / Reflux

3.1: 1,4-dioxane / 12 h / Reflux

3.2: 3 h / Reflux

4.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

5.1: isopropyl alcohol / 2 h / Reflux

6.1: trifluoroacetic acid / 2 h / Heating

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

8.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; hexane / 10 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 20 °C

10.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

12.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

13.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

14.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

With hydrogenchloride; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (2426-84-8) → (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride (1363153-79-0)

Guidance literature:

Multi-step reaction with 15 steps

1.1: potassium permanganate / acetone / 2 h / 30 - 50 °C

2.1: oxalyl dichloride / toluene / 2 h / Reflux

2.2: 2 h

3.1: acetic acid / 0.17 h / 90 °C

3.2: 1 h / Reflux

4.1: 1,4-dioxane / 12 h / Reflux

4.2: 3 h / Reflux

5.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

6.1: isopropyl alcohol / 2 h / Reflux

7.1: trifluoroacetic acid / 2 h / Heating

8.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 3 h / 20 °C

9.1: hydrogenchloride / ethyl acetate; 1,4-dioxane; hexane / 10 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 20 °C

11.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

12.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

13.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

14.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

15.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 10 h / 20 °C

With hydrogenchloride; potassium permanganate; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; hexane; dichloromethane; ethyl acetate; isopropyl alcohol; acetone; toluene;

upstream raw materials:

4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde

5-Methoxy-2-nitro-4-(phenylmethoxy)benzamide

4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline