5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Base Information

Chemical Name:5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide
CAS No.:1383717-39-2
Molecular Formula:C₂₇H₃₅N₅O₃
Molecular Weight:477.607
Hs Code.:

Synonyms:5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

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Chemical Property of 5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

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Technology Process of 5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

There total 16 articles about 5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1383717-39-2
5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:

Reference yield:

: C₄₁H₄₇N₅O₃

: 1383717-39-2
5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; at 20 ℃; for 4h; under 760.051 Torr; Sealed tube;
DOI:10.1021/jm401536b

Reference yield:

: 1383717-80-3
2,4-bis-(benzyloxy)-5-isopropylaniline

: 1383717-39-2
5-(4-cyclohexylaminomethylphenyl)-1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 7 steps

1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 13 h / 0 - 20 °C

2: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / N,N-dimethyl-formamide / 12 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: triphenylphosphine; carbon tetrabromide / dichloromethane

5: triethylamine / N,N-dimethyl-formamide / 20 °C

6: methanol / 48 h / 80 °C / Sealed tube

7: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 4 h / 20 °C / 760.05 Torr / Sealed tube

With tert.-butylnitrite; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; carbon tetrabromide; trimethylsilylazide; 10 wt% Pd(OH)2 on carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: |Huisgen Cycloaddition;
DOI:10.1021/jm401536b