3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

Base Information

Chemical Name:3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid
CAS No.:1162260-78-7
Molecular Formula:C₃₅H₄₄O₈S
Molecular Weight:624.796
Hs Code.:

Synonyms:3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

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Chemical Property of 3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

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Technology Process of 3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

There total 18 articles about 3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1162260-75-4
3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid tert-butyl ester

: 1162260-78-7
3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 56359-23-0
4-(2,3-dimethylphenoxy)butyric acid ethyl ester

: 1162260-78-7
3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

2: sodium ethanolate / ethanol / 48 h / 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

4: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

5: ethyloxirane; acetonitrile / 15 h / Heating / reflux

6: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

8: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

9: potassium carbonate / N,N-dimethyl-formamide; acetone / 24 h / 70 °C

10: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 78 °C

11: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; sodium carbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; acetone; acetonitrile; 2: Horner-Wadsworth-Emmons Olefination / 4: Wittig Reaction / 5: Wittig Reaction / 10: Suzuki Coupling;

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 1162260-78-7
3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 12 steps

1: lithium hydride / dimethyl sulfoxide / 48 h / 20 °C

2: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

3: sodium ethanolate / ethanol / 48 h / 20 °C

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

5: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

6: ethyloxirane; acetonitrile / 15 h / Heating / reflux

7: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

9: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

10: potassium carbonate / N,N-dimethyl-formamide; acetone / 24 h / 70 °C

11: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 78 °C

12: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; lithium hydride; sodium carbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; acetone; acetonitrile; 3: Horner-Wadsworth-Emmons Olefination / 5: Wittig Reaction / 6: Wittig Reaction / 11: Suzuki Coupling;