Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate

Base Information

• Chemical Name: Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate
• CAS No.: 152341-73-6
• Molecular Formula: C₂₃H₂₀N₂O₄
• Molecular Weight: 388.423
• Mol file: 152341-73-6.mol

Synonyms:Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate

Chemical Property of Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate

There total 3 articles about Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Dimethyl 3-chloro-1,4a-dihydropyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate (152341-71-4) + benzylamine (100-46-9) → Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate (152341-73-6)

Guidance literature:

With triethylamine; In benzene; for 4h; Heating;

DOI:10.1055/s-1993-25905

Reference yield:

isoquinoline (119-65-3) → Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate (152341-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / KOH / tetramethylammonium bromide / 18 °C

2: 84 percent / Et₃N / benzene / 4 h / Heating

With potassium hydroxide; triethylamine; tetramethylammonium bromide; In benzene;

DOI:10.1055/s-1993-25905

Reference yield:

dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → Dimethyl 3-(benzylamino)pyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate (152341-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / KOH / tetramethylammonium bromide / 18 °C

2: 84 percent / Et₃N / benzene / 4 h / Heating

With potassium hydroxide; triethylamine; tetramethylammonium bromide; In benzene;

DOI:10.1055/s-1993-25905

upstream raw materials:

Dimethyl 3-chloro-1,4a-dihydropyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate

benzylamine

isoquinoline

dimethyl cis-but-2-ene-1,4-dioate