1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

Base Information

• Chemical Name: 1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid
• CAS No.: 1455870-60-6
• Molecular Formula: C₁₂H₉ClF₃NO₃
• Molecular Weight: 307.657
• Mol file: 1455870-60-6.mol

Synonyms:1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

Chemical Property of 1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

There total 2 articles about 1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

cyclopropane-1,1-dicarboxylic acid (598-10-7) + 4-chloro-3-trifluoromethyl-aniline (320-51-4) → 1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid (1455870-60-6)

Guidance literature:

cyclopropane-1,1-dicarboxylic acid; With thionyl chloride; In Isopropyl acetate; at 0 - 20 ℃; for 6h;

4-chloro-3-trifluoromethyl-aniline; With triethylamine; In Isopropyl acetate; for 3h;

DOI:10.1016/j.bmcl.2017.06.041

Reference yield:

1-(chlorocarbonyl)cyclopropane-1-carboxylic acid (40258-99-9) + 4-chloro-3-trifluoromethyl-aniline (320-51-4) → 1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid (1455870-60-6)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ml500066m

Reference yield: 80.0%

1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid (1455870-60-6) + 4-(aminomethyl)aniline dihydrochloride (10003-73-3,54799-03-0,140401-57-6) → N-(4-aminobenzyl)-N'-(4-chloro-3-(trifluoromethyl)phenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2019.07.044

upstream raw materials:

1-(chlorocarbonyl)cyclopropane-1-carboxylic acid

4-chloro-3-trifluoromethyl-aniline

cyclopropane-1,1-dicarboxylic acid

Downstream raw materials:

N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-chloro-3-(trifluoromethyl)phenyl)cyclopropane-1,1-dicarboxamide