C₂₀H₁₆FN₃

Base Information

Chemical Name:C₂₀H₁₆FN₃
CAS No.:1428522-39-7
Molecular Formula:C₂₀H₁₆FN₃
Molecular Weight:317.366
Hs Code.:

C<sub>20</sub>H<sub>16</sub>FN<sub>3</sub>

Synonyms:C₂₀H₁₆FN₃

Suppliers and Price of C₂₀H₁₆FN₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₀H₁₆FN₃

Chemical Property:

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Technology Process of C₂₀H₁₆FN₃

There total 3 articles about C₂₀H₁₆FN₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 943117-82-6
2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile

: 106-49-0,12221-03-3
p-toluidine

: 1428522-39-7
C₂₀H₁₆FN₃

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate; In toluene; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1428522-39-7
C₂₀H₁₆FN₃

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 90 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; johnphos; sodium t-butanolate; trichlorophosphate; In 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 875-35-4
2,6-dichloro-4-methylnicotinonitrile

: 1428522-39-7
C₂₀H₁₆FN₃

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; johnphos; sodium t-butanolate; In 1,4-dioxane; water; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016