2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Base Information

Chemical Name:2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
CAS No.:1206123-72-9
Molecular Formula:C₂₅H₂₄F₃NO₃
Molecular Weight:443.466
Hs Code.:

Synonyms:2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

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Chemical Property of 2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

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Technology Process of 2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

There total 5 articles about 2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₈F₃NO₃

: 1206123-72-9
2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Guidance literature:: C₂₇H₂₈F₃NO₃; With water; sodium hydrogencarbonate;

In ethyl acetate; pH=4; Acidic conditions;

Reference yield:

: cyclobutylzinc(II) bromide

: 1206124-49-3
ethyl 2-(7-(4-chloro-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

: 1206123-72-9
2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; at 90 ℃; for 63h;
DOI:10.1021/ml500389m

Reference yield:

: 191348-14-8
2-iodo-4-methoxylaniline

: 1206123-72-9
2-(7-(4-cyclobutyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetraethoxy orthosilicate; pyridinium p-toluenesulfonate / N,N-dimethyl-formamide / 4 h / Heating

1.2: 3 h / 135 °C

2.1: boron tribromide / dichloromethane / 1.5 h / Cooling

3.1: caesium carbonate

4.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 63 h / 90 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tetraethoxy orthosilicate; pyridinium p-toluenesulfonate; boron tribromide; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml500389m