Technology Process of (S)-dimethyl 1-benzyl-2-phenyl-1,2-dihydrobenzo[g]quinoline-3,3(4H)-dicarboxylate
There total 6 articles about (S)-dimethyl 1-benzyl-2-phenyl-1,2-dihydrobenzo[g]quinoline-3,3(4H)-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate;
In
toluene;
at 80 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ja2014955
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C
1.2: 16 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
2.2: -78 - 0 °C
3.1: piperidine; acetic acid / benzene / 1.5 h / Reflux
4.1: (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate / toluene / 48 h / 80 °C
With
piperidine; lithium aluminium tetrahydride; oxalyl dichloride; (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate; acetic acid; dimethyl sulfoxide;
In
diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1021/ja2014955
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
1.2: -78 - 0 °C
2.1: piperidine; acetic acid / benzene / 1.5 h / Reflux
3.1: (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate / toluene / 48 h / 80 °C
With
piperidine; oxalyl dichloride; (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate; acetic acid; dimethyl sulfoxide;
In
dichloromethane; toluene; benzene;
DOI:10.1021/ja2014955
