ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

Base Information

Chemical Name:ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate
CAS No.:1432048-49-1
Molecular Formula:C₁₄H₁₃F₅O₃
Molecular Weight:324.247
Hs Code.:

Synonyms:ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

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Chemical Property of ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

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Technology Process of ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

There total 3 articles about ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

: 1432048-47-9
ethyl 3-oxo-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

: 1432048-49-1
ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 108307-56-8
2-[3-(trifluoromethoxy)phenyl]ethanenitrile

: 1432048-49-1
ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / 16.5 h / 25 - 125 °C

2: sulfuric acid / 1 h / 90 °C

3: diethylamino-sulfur trifluoride / dichloromethane / 16 h / 0 - 20 °C

With diethylamino-sulfur trifluoride; sulfuric acid; sodium t-butanolate; In dichloromethane;

Reference yield:

: 1432048-46-8
3,3-dimethoxy-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxamide

: 1432048-49-1
ethyl 3,3-difluoro-1-(3-(trifluoromethoxy)phenyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1 h / 90 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 16 h / 0 - 20 °C

With diethylamino-sulfur trifluoride; sulfuric acid; In dichloromethane;