6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

Base Information

Chemical Name:6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one
CAS No.:522614-28-4
Molecular Formula:C₂₀H₂₁N₇O₅
Molecular Weight:439.431
Hs Code.:

Synonyms:6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

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Chemical Property of 6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

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Technology Process of 6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

There total 4 articles about 6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 100-27-6
2-(4-nitrophenyl)ethanol

: 522614-26-2
6-[(acetyloxy)methyl]-2-{[(dimethylamino)methylene]amino}pteridin-4(3H)-one

: 522614-28-4
6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; at 20 ℃; for 24h;
DOI:10.1002/hlca.200390025

Reference yield: 46.0%

: 96-26-4,26776-70-5
dihydroxyacetone

: 100-27-6
2-(4-nitrophenyl)ethanol

: 4066-47-1,51324-37-9,63963-17-7
2,5,6-triaminopyrimidin-4(3H)-one dihydrochloride

: 108-24-7
acetic anhydride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1225517-12-3
7-acetoxymethyl-N⁽²⁾-(N,N-dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]pterin

: 522614-28-4
6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

Guidance literature:: dihydroxyacetone; 2,5,6-triaminopyrimidin-4(3H)-one dihydrochloride; With l-cysteine hydrochloride; sodium acetate; In water; at 20 ℃; for 2h;

In water; at 20 ℃; for 24h;

2-(4-nitrophenyl)ethanol; acetic anhydride; N,N-dimethyl-formamide dimethyl acetal; Further stages;
DOI:10.3987/COM-09-S(S)78

Reference yield:

: 712-29-8
6-(hydroxymethyl)pterin

: 522614-28-4
6-[(acetykoxy)methyl]-2-{[(dimethylamino)methylene]amino}-3-[2-(4-nitrophenyl)ethyl]pteridin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / dimethylformamide / 2 h / 20 °C

2: 76 percent / pyridine / 18 h / 20 °C

3: 71 percent / Ph₃P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C

With pyridine; di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1002/hlca.200390025