N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

Base Information

Chemical Name:N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide
CAS No.:912574-88-0
Molecular Formula:C₂₀H₁₆F₃N₅O₅S
Molecular Weight:495.439
Hs Code.:

Synonyms:N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

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Chemical Property of N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

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Technology Process of N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

There total 9 articles about N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₀F₃N₅O₆S

: 912574-88-0
N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

Guidance literature:: C₂₁H₂₀F₃N₅O₆S; With sodium hydroxide; In tetrahydrofuran; water; for 0.5h;

With hydrogenchloride; water; pH=3 - 4;

Reference yield:

: 872624-52-7
2-amino-5-iodo-4-trifluoromethyl-benzoic acid methyl ester

: 912574-88-0
N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 40 h / 100 °C

2.1: triethylamine / tetrahydrofuran / 2.5 h / 20 °C

3.1: tetrahydrofuran / 2.5 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 0.5 h

4.2: pH 3 - 4

With sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; 1.1: Stille Coupling;

Reference yield:

: 912574-86-8
1-benzyloxy-5-tributylstannanyl-1H-pyrazole

: 912574-88-0
N-[6-(2-benzyloxy-2H-pyrazol-3-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 40 h / 100 °C

2.1: triethylamine / tetrahydrofuran / 2.5 h / 20 °C

3.1: tetrahydrofuran / 2.5 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 0.5 h

4.2: pH 3 - 4

With sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; 1.1: Stille Coupling;