N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

Base Information

Chemical Name:N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide
CAS No.:912998-90-4
Molecular Formula:C₂₅H₂₃FN₂O₃
Molecular Weight:418.468
Hs Code.:

Synonyms:N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

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Technology Process of N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

There total 3 articles about N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.5%

: 500-22-1
3-pyridinecarboxaldehyde

: 693793-65-6
2-benzylidene-4-methyl-3-oxo-pentanoic acid (4-fluoro-phenyl)-amide

: 912998-90-4
N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

Guidance literature:: With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; In ethanol; at 80 ℃; for 24h;

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 912998-90-4
N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / toluene / 5 h / 80 °C

2: toluene / 24 h / Heating / reflux

3: acetic acid; 3-amino propanoic acid / hexanes / 28 h / Heating / reflux

4: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 24 h / 80 °C

With sodium hydride; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; 3-amino propanoic acid; In hexanes; ethanol; toluene;

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 912998-90-4
N-(4-fluorophenyl)-4-methyl-3-oxo-2-(2-oxo-1-phenyl-2-(pyridin-3-yl)ethyl)pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 24 h / Heating / reflux

2: acetic acid; 3-amino propanoic acid / hexanes / 28 h / Heating / reflux

3: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 24 h / 80 °C

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; 3-amino propanoic acid; In hexanes; ethanol; toluene;