(E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

Base Information

Chemical Name:(E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate
CAS No.:118459-80-6
Molecular Formula:C₃₀H₃₀O₆
Molecular Weight:486.565
Hs Code.:

Synonyms:(E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

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Chemical Property of (E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

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Technology Process of (E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

There total 1 articles about (E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 118459-79-3
(E)-benzyl 3-(4-bromophenyl)acrylate

: 118459-78-2,118459-93-1
(E/Z)-tert-butyl 3-hydroxy-4-methoxycinnamate

: 118459-94-2
(Z,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

: 118459-80-6
(E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

Guidance literature:: With potassium carbonate; copper(II) oxide; In pyridine; at 145 ℃; for 24h;
DOI:10.1021/ja00185a042

Reference yield:

: 118459-80-6
(E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

: 118459-95-3
3-{4-[5-(2-tert-Butoxycarbonyl-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; acetic acid; for 10h; Yield given;
DOI:10.1021/ja00185a042

Reference yield:

: 118459-80-6
(E,E)-1,1-dimethylethyl 3-<4-<3-oxo-3-(phenylmethoxy)propenyl>phenoxy>-4-methoxybenzenepropenoate

: 118629-52-0
(S)-2-Amino-3-{4-[5-(2-carboxy-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C / ethanol; acetic acid / 10 h

2: Et₃N / tetrahydrofuran / 1.) 78 deg C, 15 min; 2.) 0 deg C, 45 min

3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C; 2.) hexane, THF, -78 deg C, 15 min and then to room temp., 1.5 h

4: 1.) KHMDS, 2.) trisyl azide / 1.) THF, toluene, -78 deg C, 15 min, 2.) THF, toluene, -78 deg C, 2 min

5: 1.) titanium tetraisopropoxide / 2.) 70 deg C, 2 h

6: H₂ / Raney Ni / CH₂Cl₂; acetic acid / 6.5 h

7: trifluoroacetic acid, thioanisole / CH₂Cl₂ / 1 h / 0 deg C --> room temp.

With titanium(IV) isopropylate; n-butyllithium; methyl-phenyl-thioether; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; triethylamine; trifluoroacetic acid; palladium on activated charcoal; nickel; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja00185a042