(E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester

Base Information

• Chemical Name: (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester
• CAS No.: 164660-21-3
• Molecular Formula: C₁₈H₂₇NO₂
• Molecular Weight: 289.418
• Mol file: 164660-21-3.mol

Synonyms:(E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester

Chemical Property of (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester

There total 4 articles about (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3R,4E,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-hept-4-enoate (164660-17-7) → (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester (164660-21-3)

Guidance literature:

With Wilkinson's catalyst; In water; acetonitrile;

DOI:10.1039/c39950001109 DOI:10.1016/S0957-4166(97)00470-9

Reference yield:

sorbic Acid (110-44-1,91751-55-2) → (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester (164660-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. H₂SO₄

2: 78 percent / 1 h / -78 °C

3: 92 percent / (PPh₃)3RhCl / acetonitrile; H₂O

With Wilkinson's catalyst; sulfuric acid; In water; acetonitrile;

DOI:10.1016/S0957-4166(97)00470-9

Reference yield:

tert-butyl (2E,4E)-2,4-hexadienoate (81838-85-9) → (E)-(R)-3-((S)-1-Phenyl-ethylamino)-hex-4-enoic acid tert-butyl ester (164660-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 1 h / -78 °C

2: 92 percent / (PPh₃)3RhCl / acetonitrile; H₂O

With Wilkinson's catalyst; In water; acetonitrile;

DOI:10.1016/S0957-4166(97)00470-9

upstream raw materials:

(3R,4E,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-hept-4-enoate

sorbic Acid

tert-butyl (2E,4E)-2,4-hexadienoate

Downstream raw materials:

(E)-(R)-3-(Benzoyl-tert-butoxycarbonyl-amino)-hex-4-enoic acid methyl ester

(E)-(R)-3-Benzoylamino-hex-4-enoic acid methyl ester

(E)-(R)-3-[Benzoyl-((S)-1-phenyl-ethyl)-amino]-hex-4-enoic acid tert-butyl ester