3--trans-2,3-epoxy-1-propanol

Base Information

Chemical Name:3--trans-2,3-epoxy-1-propanol
CAS No.:137571-45-0
Molecular Formula:C₁₅H₂₂O₃
Molecular Weight:250.338
Hs Code.:

3-<m-(Hydroxy-3-methylpentyl)phenyl>-trans-2,3-epoxy-1-propanol

Synonyms:3--trans-2,3-epoxy-1-propanol

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Chemical Property of 3--trans-2,3-epoxy-1-propanol

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Technology Process of 3--trans-2,3-epoxy-1-propanol

There total 9 articles about 3--trans-2,3-epoxy-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137571-44-9
3--(E)-2-propen-1-ol

: 137571-45-0
3--trans-2,3-epoxy-1-propanol

Guidance literature:: With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; 4 A molecular sieve; In dichloromethane; at -20 ℃;
DOI:10.1021/jo00029a033

Reference yield:

: 99-36-5
1-methoxycarbonyl-3-methylbenzene

: 137571-45-0
3--trans-2,3-epoxy-1-propanol

Guidance literature:: Multi-step reaction with 9 steps

1: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

2: NEt₃ / tetrahydrofuran / 1.5 h / 0 °C

3: 82 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

4: 1) n-BuLi / 1) THF, hexane, -78 deg C, 15 min, 2a) -78 deg C, 5 min, b) to r.t.

5: 89 percent / n-Bu₃SnH, AIBN / benzene / 2.5 h / Heating

6: 1) Me₂S*BH₃, 2) 3 N NaOH, H₂O₂ / 1) THF, Et₂O, -20 deg C, 2) MeOH

7: activated MnO₂ / CHCl₃

8: tetrahydrofuran / Ambient temperature

9: 4 Angstroem molecular sieves, VO(acac)2, t-BuOOH / CH₂Cl₂ / -20 °C

With tert.-butylhydroperoxide; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; Perbenzoic acid; bis(acetylacetonate)oxovanadium; 2,2'-azobis(isobutyronitrile); dimethylsulfide borane complex; 4 A molecular sieve; dihydrogen peroxide; tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1021/jo00029a033

Reference yield:

: 137571-41-6
m-<(E)-3-Methyl-3-pentenyl>benzyl alcohol

: 137571-45-0
3--trans-2,3-epoxy-1-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Me₂S*BH₃, 2) 3 N NaOH, H₂O₂ / 1) THF, Et₂O, -20 deg C, 2) MeOH

2: activated MnO₂ / CHCl₃

3: tetrahydrofuran / Ambient temperature

4: 4 Angstroem molecular sieves, VO(acac)2, t-BuOOH / CH₂Cl₂ / -20 °C

With tert.-butylhydroperoxide; manganese(IV) oxide; sodium hydroxide; bis(acetylacetonate)oxovanadium; dimethylsulfide borane complex; 4 A molecular sieve; dihydrogen peroxide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00029a033