3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester

Base Information

• Chemical Name: 3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester
• CAS No.: 102423-14-3
• Molecular Formula: C₄₀H₄₈N₂O₈Si
• Molecular Weight: 712.915
• Mol file: 102423-14-3.mol

Synonyms:3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester

Chemical Property of 3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester

There total 1 articles about 3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (64722-98-1) + Allyl chloroformate (2937-50-0) → 3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester (102423-14-3)

Guidance literature:

With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jo00362a052

Reference yield: 97.0%

3-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid allyl ester (102423-14-3) → 1-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (64722-98-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; triphenylphosphine; In tetrahydrofuran; at 20 - 25 ℃; for 0.0833333h;

DOI:10.1021/jo00362a052

upstream raw materials:

1-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Allyl chloroformate

Downstream raw materials:

1-{(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione