4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

Base Information

Chemical Name:4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester
CAS No.:343981-63-5
Molecular Formula:C₁₈H₁₉F₃N₂O₃
Molecular Weight:368.356
Hs Code.:

Synonyms:4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

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Chemical Property of 4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

Chemical Property:

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Technology Process of 4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

There total 3 articles about 4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)phenyl)propanoate

: 343981-63-5
4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 343981-57-7
3-iodo-1,6-dimethyl-4-(trifluoromethyl)pyridin-2(1H)-one

: 343981-63-5
4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); potassium phosphate / 1,2-dimethoxyethane; water / 0.2 h / 77 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; ethyl acetate / 2 h / 20 °C

With hydrogenchloride; potassium phosphate; palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); In 1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate;

Reference yield:

: 224824-22-0
(S)-(4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)boronic acid

: 343981-63-5
4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); potassium phosphate / 1,2-dimethoxyethane; water / 0.2 h / 77 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; ethyl acetate / 2 h / 20 °C

With hydrogenchloride; potassium phosphate; palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); In 1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate;