cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide

Base Information

• Chemical Name: cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide
• CAS No.: 1258294-26-6
• Molecular Formula: C₁₇H₁₅Cl₂N₃O₃
• Molecular Weight: 380.23

Synonyms:cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide

Chemical Property of cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide

Chemical Property:

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Technology Process of cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide

There total 3 articles about cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2,6-dichloro-N-(2-(2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-4-yl)benzamide (1258298-13-3) → 2,6-dichloro-N-(2-((1R,2S)-2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide (1258294-25-5) + cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide (1258294-26-6)

Guidance literature:

With sodium tetrahydroborate; In water; isopropyl alcohol; at 20 ℃; for 1h;

DOI:10.1021/jm400266t

Reference yield:

N-(2-aminopyridin-4-yl)-2,6-dichlorobenzamide (1258291-83-6) → 2,6-dichloro-N-(2-((1R,2S)-2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide (1258294-25-5) + cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide (1258294-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

2: sodium tetrahydroborate / water; isopropyl alcohol / 1 h / 20 °C

With sodium tetrahydroborate; In 1,4-dioxane; water; isopropyl alcohol;

DOI:10.1021/jm400266t

Reference yield:

3-oxabicyclo[3.1.0]hexane-2,4-dione (5617-74-3) → 2,6-dichloro-N-(2-((1R,2S)-2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide (1258294-25-5) + cis-2,6-dichloro-N-(2-(2-(hydroxymethyl)cyclopropanecarboxamido)pyridin-4-yl)benzamide (1258294-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

2: sodium tetrahydroborate / water; isopropyl alcohol / 1 h / 20 °C

With sodium tetrahydroborate; In 1,4-dioxane; water; isopropyl alcohol;

DOI:10.1021/jm400266t

upstream raw materials:

2,6-dichloro-N-(2-(2,4-dioxo-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-4-yl)benzamide

N-(2-aminopyridin-4-yl)-2,6-dichlorobenzamide

3-oxabicyclo[3.1.0]hexane-2,4-dione

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