1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Base Information

Chemical Name:1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid
CAS No.:1437323-23-3
Molecular Formula:C₁₅H₁₃FN₂O₄
Molecular Weight:304.278
Hs Code.:

Synonyms:1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Chemical Property:

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Technology Process of 1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

There total 5 articles about 1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1446424-72-1
ethyl 1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1437323-23-3
1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 70 ℃; for 5h;
DOI:10.1016/j.bmcl.2021.128247

Reference yield:

: 1437323-24-4
2-[3-(4-fluorophenyl)ureidomethylene]malonic acid diethyl ester

: 7051-34-5
cyclopropylcarbinyl bromide

: 1437323-23-3
1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Guidance literature:: 2-[3-(4-fluorophenyl)ureidomethylene]malonic acid diethyl ester; With potassium carbonate; In ethanol; at 75 ℃; for 2h; Inert atmosphere;

cyclopropylcarbinyl bromide; In ethanol; at 75 ℃; for 16h; Inert atmosphere;

In ethanol; water; at 75 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1437323-25-5
3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

: 1437323-23-3
1-(cyclopropylmethyl)-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 65 °C

2: lithium hydroxide / methanol; tetrahydrofuran / 6 h / 20 °C

With potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;