2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Base Information

• Chemical Name: 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
• CAS No.: 221658-96-4
• Molecular Formula: C₁₆H₁₇I₂N₃O₂S
• Molecular Weight: 569.205
• Mol file: 221658-96-4.mol

Synonyms:2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Chemical Property of 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

There total 7 articles about 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.7%

N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido (221658-95-3) → 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (221658-96-4)

Guidance literature:

N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido; With trichlorophosphate; In CH₃CN; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;

Reference yield:

N-[4-(3,5-diiodo-4-methoxy-benzyl)-6,7-dihydro-thiazolo[5,4-c]pyridin-2-yl]-acetamide → 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (221658-96-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; Yield given; Ambient temperature;

DOI:10.1021/jm990012z

Reference yield:

2-[2-(2-amino-1,3-thiazol-4-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide (95914-09-3) → 2-acetamido-4-(3',5'-diiodo-4'-methoxyphenylmethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (221658-96-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 30 percent aq. HBr / Heating

2: NaOH / CHCl₃ / 1.5 h / Ambient temperature

3: 92 percent / acetonitrile; benzene / 2.5 h / Heating

4: POCl₃ / acetonitrile / 5 h / Heating

5: NaBH₄ / methanol / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; hydrogen bromide; trichlorophosphate; In methanol; chloroform; acetonitrile; benzene;

DOI:10.1021/jm990012z

upstream raw materials:

2-[2-(2-amino-1,3-thiazol-4-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide

3,5-diiodo-4-methoxyphenylacetyl chloride

N-2-<(2-amino-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido

N-2-<(2-acetamido-4-thiazolyl)ethyl>-3,5-diiodo-4-methoxyphenylacetamido