(Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate

Base Information

• Chemical Name: (Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate
• CAS No.: 1397372-74-5
• Molecular Formula: C₁₈H₂₅N₅O₂S
• Molecular Weight: 375.495
• Mol file: 1397372-74-5.mol

Synonyms:(Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate

Chemical Property of (Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate

There total 2 articles about (Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(Z)-4-hydroxybut-1-enyl diisopropylcarbamate (1397372-70-1) + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → (Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate (1397372-74-5)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine;

DOI:10.1016/j.tetlet.2012.06.142

Reference yield:

N,N-Diisopropylcarbamidsaeure-(2-propenylester) (74562-19-9) → (Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate (1397372-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (-)-sparteine; n-butyllithium / toluene / 2.5 h / -78 °C

1.2: 0.5 h / -78 °C

1.3: 1 h / -78 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine; (-)-sparteine; In tetrahydrofuran; toluene;

DOI:10.1021/acs.joc.8b02033

Reference yield: 91.0%

(Z)-4-(1-phenyl-1H-tetrazol-5-ylthio)but-1-enyl diisopropylcarbamate (1397372-74-5) → (Z)-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)but-1-enyl diisopropylcarbamate (1397372-66-5)

Guidance literature:

With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In ethanol;

DOI:10.1016/j.tetlet.2012.06.142

upstream raw materials:

(Z)-4-hydroxybut-1-enyl diisopropylcarbamate

1-Phenyl-1H-tetrazole-5-thiol

N,N-Diisopropylcarbamidsaeure-(2-propenylester)

Downstream raw materials:

C₁₇H₂₆N₄O₄SSi

(Z)-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)but-1-enyl diisopropylcarbamate