1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone
• CAS No.: 153773-58-1
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 153773-58-1.mol

Synonyms:1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone

Chemical Property of 1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone

There total 1 articles about 1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-hydroxymethyl-1-(4-methoxyphenyl)-2-azetidinone (145985-24-6) → 1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone (153773-58-1)

Guidance literature:

With pyridinium p-toluenesulfonate; bentonite; In dichloromethane; for 48h; Ambient temperature;

Reference yield:

1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone (153773-58-1) → trans-3-amino-1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone

Guidance literature:

Multi-step reaction with 2 steps

2: 99 percent / H₂i38 / 10percent Pd/C / tetrahydrofuran

With H₂i38; palladium on activated charcoal; In tetrahydrofuran;

Reference yield:

1-(4-methoxyphenyl)-4-<(tetrahydropyran-2-yl)oxymethyl>-2-azetidinone (153773-58-1) → [(3R,4S)-1-(4-Methoxy-phenyl)-2-oxo-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-3-yl]-carbamic acid benzyl ester

Guidance literature:

Multi-step reaction with 3 steps

2: 99 percent / H₂i38 / 10percent Pd/C / tetrahydrofuran

3: NaHCO₃ / tetrahydrofuran; H₂O / Ambient temperature

With sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; water;

upstream raw materials:

3,4-dihydro-2H-pyran

4-hydroxymethyl-1-(4-methoxyphenyl)-2-azetidinone

Downstream raw materials:

3,3-Diazido-1-(4-methoxy-phenyl)-4-(tetrahydro-pyran-2-yloxymethyl)-azetidin-2-one