Technology Process of (3R,5R)-3-(2,5-dimethoxy-4-methylphenyl)-6-methylheptane-1,5,6-triol
There total 3 articles about (3R,5R)-3-(2,5-dimethoxy-4-methylphenyl)-6-methylheptane-1,5,6-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1039/c0cc00481b
- Guidance literature:
-
Multi-step reaction with 5 steps
1: AD-mix-β; methanesulfonamide / water; tert-butyl alcohol / 0 °C / Inert atmosphere
2: quinoline; hydrogen / ethanol / 2.5 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / toluene / 25 °C / Inert atmosphere
4: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; triphenylphosphine / chloroform; toluene / 20 - 60 °C / Inert atmosphere
5: lithium borohydride / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
With
quinoline; tris-(dibenzylideneacetone)dipalladium(0); lithium borohydride; methanesulfonamide; AD-mix-β; hydrogen; caesium carbonate; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; chloroform; water; toluene; tert-butyl alcohol;
DOI:10.1007/s11426-010-4173-y
- Guidance literature:
-
Multi-step reaction with 4 steps
1: quinoline; hydrogen / ethanol / 2.5 h / 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / toluene / 25 °C / Inert atmosphere
3: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; triphenylphosphine / chloroform; toluene / 20 - 60 °C / Inert atmosphere
4: lithium borohydride / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere
With
quinoline; tris-(dibenzylideneacetone)dipalladium(0); lithium borohydride; hydrogen; caesium carbonate; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; chloroform; toluene;
DOI:10.1007/s11426-010-4173-y