Technology Process of C46H56N4O8SSi
There total 10 articles about C46H56N4O8SSi which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5H-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid tert-butyl ester;
In
(2)H8-toluene;
at 110 ℃;
for 2h;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
at 20 ℃;
for 2h;
DOI:10.1021/ol0617547
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 86 percent / imidazole / dimethylformamide / 16 h / 40 °C
2.1: 85 percent / LiCl; CuCl / Pd(PPh3)4 / dimethylsulfoxide / 0.5 h / 20 °C
3.1: 82 percent / NaOAc / Pd(PPh3)4 / dimethylformamide / 2 h / 150 °C
4.1: 80 percent / N-methylmorpholine-N-oxide; OsO4; NaIO4 / tetrahydrofuran; H2O / 20 h / 20 °C
5.1: Pd(OAc)2 / acetonitrile / 20 h / 20 °C
6.1: 917 mg / LiHMDS / tetrahydrofuran / -78 - -50 °C
7.1: 86 percent / iodine / CCl4; pyridine / 24 h / 20 °C
8.1: 71 percent / LiCl; CuCl / Pd(PPh3)4 / dimethylsulfoxide / 0.5 h / 20 °C
9.1: toluene-d8 / 2 h / 110 °C
9.2: 72 percent / DDQ / 2 h / 20 °C
With
1H-imidazole; sodium periodate; osmium(VIII) oxide; iodine; sodium acetate; 4-methylmorpholine N-oxide; copper(l) chloride; lithium chloride; lithium hexamethyldisilazane;
palladium diacetate; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; pyridine; tetrachloromethane; (2)H8-toluene; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
2.1: Stille coupling reaction / 3.1: Heck reaction / 4.1: Saegusa oxidation / 5.1: Saegusa oxidation / 8.1: Stille coupling reaction;
DOI:10.1021/ol0617547
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 85 percent / LiCl; CuCl / Pd(PPh3)4 / dimethylsulfoxide / 0.5 h / 20 °C
2.1: 82 percent / NaOAc / Pd(PPh3)4 / dimethylformamide / 2 h / 150 °C
3.1: 80 percent / N-methylmorpholine-N-oxide; OsO4; NaIO4 / tetrahydrofuran; H2O / 20 h / 20 °C
4.1: Pd(OAc)2 / acetonitrile / 20 h / 20 °C
5.1: 917 mg / LiHMDS / tetrahydrofuran / -78 - -50 °C
6.1: 86 percent / iodine / CCl4; pyridine / 24 h / 20 °C
7.1: 71 percent / LiCl; CuCl / Pd(PPh3)4 / dimethylsulfoxide / 0.5 h / 20 °C
8.1: toluene-d8 / 2 h / 110 °C
8.2: 72 percent / DDQ / 2 h / 20 °C
With
sodium periodate; osmium(VIII) oxide; iodine; sodium acetate; 4-methylmorpholine N-oxide; copper(l) chloride; lithium chloride; lithium hexamethyldisilazane;
palladium diacetate; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; pyridine; tetrachloromethane; (2)H8-toluene; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
1.1: Stille coupling reaction / 2.1: Heck reaction / 3.1: Saegusa oxidation / 4.1: Saegusa oxidation / 7.1: Stille coupling reaction;
DOI:10.1021/ol0617547
![4-{3-methoxy-5-oxo-2-[1-(toluene-4-sulfonyl)-1<i>H</i>-indol-3-yl]-9-triisopropylsilanyloxy-8,9-dihydro-5<i>H</i>-cycloheptapyrazin-6-yl}-2,2-dimethyl-5-vinyl-oxazole-3-carboxylic acid <i>tert</i>-butyl ester](/Databaselist/images/loading.webp)
