1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide

Base Information

• Chemical Name: 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide
• CAS No.: 54610-33-2
• Molecular Formula: C₁₉H₂₄N₂O₃
• Molecular Weight: 328.411

Synonyms:1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide

Chemical Property of 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide

Chemical Property:

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Technology Process of 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide

There total 5 articles about 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-diformyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide (54610-09-2) → 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide (54610-33-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; Ambient temperature;

DOI:10.1021/jm00182a024

Reference yield:

2,4,5,6-tetrahydro-1,3-diformyl-4,6,6-trimethyl-2-phenylcyclopentapyrrole-4-carbonitrile (54649-60-4) → 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide (54610-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 91percent H₂SO₄ / Ambient temperature

2: NABH₄ / ethanol / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; In ethanol;

DOI:10.1021/jm00182a024

Reference yield:

1,3-bis(dichloromethyl)-2,4,5,6-tetrahydro-4,6,6-trimethyl-2-phenylcyclopentapyrrole-4-carbonitrile (54609-67-5) → 1,3-bis-hydroxymethyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide (54610-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / ethanol; H₂O / 1 h / Heating

2: 91percent H₂SO₄ / Ambient temperature

3: NABH₄ / ethanol / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; In ethanol; water;

DOI:10.1021/jm00182a024

upstream raw materials:

1,3-diformyl-4,6,6-trimethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carboxylic acid amide

2,4,5,6-tetrahydro-1,3-diformyl-4,6,6-trimethyl-2-phenylcyclopentapyrrole-4-carbonitrile

1,3-bis(dichloromethyl)-2,4,5,6-tetrahydro-4,6,6-trimethyl-2-phenylcyclopentapyrrole-4-carbonitrile

1,3,4,6,6-pentamethyl-2-phenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrrole-4-carbonitrile

Downstream raw materials:

2-phenyl-2,4,5,6-tetrahydro-1,3-bis-methoxymethyl-4,6,6-trimethylcyclopenta[c]pyrrole-4-carboxamide

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