N-Boc-D-alaninol

Base Information

• Chemical Name: N-Boc-D-alaninol
• CAS No.: 106391-86-0
• Molecular Formula: C₈H₁₇NO₃
• Molecular Weight: 175.228
• Hs Code.: 29051990
• Mol file: 106391-86-0.mol

Synonyms:Carbamicacid, (2-hydroxy-1-methylethyl)-, 1,1-dimethylethyl ester, (R)-;Carbamic acid,[(1R)-2-hydroxy-1-methylethyl]-, 1,1-dimethylethyl ester (9CI);((1R)-2-Hydroxy-1-methylethyl)carbamic acid tert-butyl ester;((R)-2-Hydroxy-1-methylethyl)carbamic acid tert-butyl ester;(R)-(+)-2-(tert-Butoxycarbonylamino)-1-propanol;(R)-2-(N-tert-Butoxycarbonyl)aminopropan-1-ol;(R)-2-(tert-Butoxycarbonylamino)-1-propanol;(R)-2-[(tert-Butyloxycarbonyl)amino]propan-1-ol;N-(tert-Butoxycarbonyl)-D-alaninol;tert-Butyl((1R)-2-hydroxy-1-methylethyl)carbamate;Boc-D-Ala-ol;

Chemical Property of N-Boc-D-alaninol

Chemical Property:

• Vapor Pressure: 0.000597mmHg at 25°C
• Melting Point: 58-61 °C(lit.)
• Refractive Index: 1.45
• Boiling Point: 276.4 °C at 760 mmHg
• PKA: 12.11±0.46(Predicted)
• Flash Point: 121 °C
• PSA: 58.56000
• Density: 1.025 g/cm³
• LogP: 1.28280
• Storage Temp.: Store at 0°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Boc-D-alaninol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used in the synthesis of antithrombotic nipecotamides.

Technology Process of N-Boc-D-alaninol

There total 23 articles about N-Boc-D-alaninol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-aminopropan-1-ol (35320-23-1) + di-tert-butyl dicarbonate (24424-99-5) → (R)-2-tertbutoxycarbonylamino-1-propanol (79069-13-9,127516-56-7,147252-84-4,106391-86-0)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2021.113785

Reference yield: 100.0%

1-benzyloxy-2(S)-t-butoxycarbonylamino-3-ethylthiopropane (167421-97-8) → (R)-2-tertbutoxycarbonylamino-1-propanol (79069-13-9,127516-56-7,147252-84-4,106391-86-0)

Guidance literature:

nickel; In ethanol; water; Heating;

DOI:10.1016/0040-4039(95)00039-F

Reference yield: 97.0%

methyl 2-{[(tert-butoxy)carbonyl]amino}propanoate (112392-66-2) → tert-butyl (1-hydroxypropan-2-yl)carbamate (147252-84-4,79069-13-9,106391-86-0,127516-56-7)

Guidance literature:

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.37.3119

upstream raw materials:

(R)-2-aminopropan-1-ol

di-tert-butyl dicarbonate

N-(tert-butoxycarbonyl)-D-alanine methyl ester

1-benzyloxy-2(S)-t-butoxycarbonylamino-3-ethylthiopropane

Downstream raw materials:

N-t-butyloxycarbonyl-DL-alanine

(2R)-2-[(tert-butoxycarbonyl)amino]propyl methanesulfonate

2-chloro-N-{(R)-1-[5-phenyl-(1,2,4-triazol-3-yl)]thio-2-propyl}adenosine

2-chloro-N-[(R)-1-(4-phenyl-2-thiazolyl)thio-2-propyl]adenosine

Refernces

• 1、 Fujii,Itaya,Yoshida,Matsubara. "Purines. XXXV.(1))Synthesis and cytokinin activity of racemin 1'-Methylzeatin". . p. 3119 - 3121. Retrieved 1989.
• 2、 Das, Kalyan,De Jonghe, Steven,Gu, Weijie,Herdewijn, Piet,Martinez, Sergio,Nguyen, Hoai,Rozenski, Jef,Schols, Dominique,Singh, Abhimanyu K.. "Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design". . . Retrieved 2021.
• 3、 Bartoszak-Adamska, El?bieta,Go?dyn, Mateusz,Koroniak, Henryk,Koroniak-Szejn, Katarzyna,Salamon-Krokosz, Katarzyna,Siod?a, Tomasz. "Fluorinated Olefinic Lactams: The Case of Amino Acids - Preparation and Mechanistic Studies". . . Retrieved 2022/03/17.
• 4、 -. "HETEROCYCLIC COMPOUNDS". Paragraph 0224; 0281. . Retrieved 2020/12/29.