(23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

Base Information

Chemical Name:(23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether
CAS No.:241820-79-1
Molecular Formula:C₄₀H₆₀O₇S
Molecular Weight:684.978
Hs Code.:

Synonyms:(23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

Suppliers and Price of (23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

There total 2 articles about (23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 98-59-9
p-toluenesulfonyl chloride

: 241820-77-9
(23E)-(1S,3R,20S,22S)-22-(2-hydroxyethyl)-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

: 241820-79-1
(23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

Guidance literature:: With pyridine; at 0 ℃; for 26h;
DOI:10.1021/jm0105631

Reference yield:

: (23E)-(1S,3R,20S)-22-(ethoxycarbonyl)methyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 1,3-bis(methyl carbonate) 25-methoxymethyl ether

: 241820-79-1
(23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / DIBAL / hexane; CH₂Cl₂ / 1 h / -20 °C

2: 55 percent / pyridine / 26 h / 0 °C

With pyridine; diisobutylaluminium hydride; In hexane; dichloromethane;
DOI:10.1021/jm0105631

Reference yield:

: 241820-79-1
(23E)-(1S,3R,20S,22S)-22-[2-(4-methylbenzene)sulfonyloxy]ethyl-24a,24b-dihomo-5,7,23-cholestatriene-1,3,25-triol 25-methoxymethyl ether

: (22S)-22-Ethyl-1,25-dihydroxy-23,24-didehydro-24a,24b-dihomo-20-epivitamin D₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: 44 percent / LAH / tetrahydrofuran / 0.33 h / Heating

2.1: 63 percent / aq. TsOH / ethanol / 0.25 h / Heating

3.1: benzene; ethanol / 0 °C / UV-irradiation

3.2: aq. ethanol / 20 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jm0105631