(3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid

Base Information

Chemical Name:(3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid
CAS No.:66967-01-9
Molecular Formula:C₁₃H₂₅NO₅
Molecular Weight:275.345
Hs Code.:
DSSTox Substance ID:DTXSID90428476
Nikkaji Number:J258.861G
Wikidata:Q82241315

Synonyms:66967-01-9;Boc-epi-statine;(3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid;(3R,4S)-4-((tert-Butoxycarbonyl)amino)-3-hydroxy-6-methylheptanoic acid;Boc-(3R,4S)Sta-OH;epi-Boc-Statine;(3R,4S)-4-[(tert-Butoxycarbonyl)amino]-3-hydroxy-6-methylheptanoic acid;SCHEMBL7828875;DTXSID90428476;MFCD00063179;AKOS030212184;AS-47666;F15113;Boc-Sta(3R,4S)-OH, >=97.0% (sum of enantiomers, HPLC);(3R,4S)-4-((tert-Butoxycarbonyl)amino)-3-hydroxy-6-methylheptanoicacid;Heptanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-6-methyl-, (3R,4S)-;Heptanoic acid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-6-methyl-,(3R,4S)-;(3R,4S)-N-t-Butyloxycarbonyl-statine, (3R,4S)-3-Hydroxy-4-Boc-amino-6-methyl-heptanoic acid

Suppliers and Price of (3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Iris Biotech GmbH
Boc-(3R,4S)Sta-OH
250 mg
$ 337.50

Iris Biotech GmbH
Boc-(3R,4S)Sta-OH
1 g
$ 1012.50

Crysdot
(3R,4S)-4-((tert-Butoxycarbonyl)amino)-3-hydroxy-6-methylheptanoicacid 97%
5g
$ 982.00

Crysdot
(3R,4S)-4-((tert-Butoxycarbonyl)amino)-3-hydroxy-6-methylheptanoicacid 97%
1g
$ 327.00

Biosynth Carbosynth
Boc-epi-statine (3R,4S)-4-(Boc-amino)-3-hydroxy-6-methyl-heptanoic acid
100 mg
$ 262.00

Biosynth Carbosynth
Boc-epi-statine (3R,4S)-4-(Boc-amino)-3-hydroxy-6-methyl-heptanoic acid
1 g
$ 1550.00

Biosynth Carbosynth
Boc-epi-statine (3R,4S)-4-(Boc-amino)-3-hydroxy-6-methyl-heptanoic acid
50 mg
$ 151.00

AK Scientific
(3R,4S)-3-Hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoicacid
100mg
$ 403.00

AK Scientific
(3R,4S)-3-Hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoicacid
50mg
$ 253.00

Total 12 raw suppliers

Chemical Property of (3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid

Chemical Property:

Appearance/Colour:white - off-white powder
Melting Point:137-139ºC
PSA：95.86000
LogP:2.15230
Storage Temp.:2-8°C
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:275.17327290
Heavy Atom Count:19
Complexity:309

Purity/Quality:

99% ^*data from raw suppliers

Boc-(3R,4S)Sta-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(CC(=O)O)O)NC(=O)OC(C)(C)C
Isomeric SMILES:CC(C)C[C@@H]([C@@H](CC(=O)O)O)NC(=O)OC(C)(C)C

Technology Process of (3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid

There total 42 articles about (3R,4S)-3-hydroxy-6-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 254752-31-3
(3R,4S)-4-(tert-butoxycarbonylamino)-6-methyl-1-trimethylsilylhept-1-yn-3-ol

: 66967-01-9
(3R,4S)-3-hydroxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methylheptanoic acid

Guidance literature:: (3R,4S)-4-(tert-butoxycarbonylamino)-6-methyl-1-trimethylsilylhept-1-yn-3-ol; With bis(cyclohexanyl)borane; In tetrahydrofuran; at 20 ℃; for 1.5h;

With dihydrogen peroxide; In sodium hydrogencarbonate; at 20 ℃; for 3h;

With acetic acid; at 0 - 20 ℃; Further stages.;
DOI:10.1021/ol991098t

Reference yield: 75.0%

: 936226-65-2
(2S,3R)-tert-butyl 3-hydroxy-2-isobutyl-5-oxopyrrolidine-1-carboxylate

: 66967-01-9
(3R,4S)-3-hydroxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methylheptanoic acid

Guidance literature:: (2S,3R)-tert-butyl 3-hydroxy-2-isobutyl-5-oxopyrrolidine-1-carboxylate; With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;
DOI:10.1021/ol802685e