2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Base Information

Chemical Name:2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine
CAS No.:511277-71-7
Molecular Formula:C₂₇H₂₈N₂O₂
Molecular Weight:412.532
Hs Code.:

Synonyms:2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

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Chemical Property of 2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

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Technology Process of 2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

There total 4 articles about 2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 198209-31-3
2-bromo6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

: 511277-69-3
4-benzyloxy-5-ethyl-2-methoxy-phenylboronic acid

: 511277-71-7
2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; for 64h; Heating / reflux;

Reference yield:

: 19672-02-7
5-ethyl-2-methoxyphenyl

: 511277-71-7
2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃

2.1: NBS; silica gel / CCl₄

3.1: BuLi / tetrahydrofuran / -78 °C

3.2: B(OEt)3 / tetrahydrofuran

4.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; silica gel; sodium carbonate; potassium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol; 4.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 511277-65-9
3-benzyloxy-4-ethyl-1-methoxybenzene

: 511277-71-7
2-(4-benzyloxy-5-ethyl-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: NBS; silica gel / CCl₄

2.1: BuLi / tetrahydrofuran / -78 °C

2.2: B(OEt)3 / tetrahydrofuran

3.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; silica gel; sodium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043