dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate

Base Information

• Chemical Name: dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate
• CAS No.: 942268-04-4
• Molecular Formula: C₁₆H₁₉NO₈
• Molecular Weight: 353.329
• Mol file: 942268-04-4.mol

Synonyms:dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate

Chemical Property of dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate

Chemical Property:

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Technology Process of dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate

There total 1 articles about dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + dimethyl [N-(4-methoxyphenyl)aminomalonate] (35757-94-9) → dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate (942268-04-4)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/ol070674f

Reference yield:

dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate (942268-04-4) + 1-(naphthalen-1-yl)prop-2-yn-1-one (28274-53-5) → (+/-)-(3R,4R)-3,5,5-tricarbomethoxy-1-(4-methoxyphenyl)-4-[2-(1-naphthyl)-2-oxoethyl]pyrrolidin-2-one + (+/-)-(3R,4S)-3,5,5-tricarbomethoxy-1-(4-methoxyphenyl)-4-[2-(1-naphthyl)-2-oxoethyl]pyrrolidin-2-one

Guidance literature:

With bis(acetylacetonate)nickel(II); potassium tert-butylate; In dichloromethane; at 20 ℃; for 16h; Title compound not separated from byproducts.;

DOI:10.1021/ol070674f

Reference yield:

dimethyl N-(2-carbomethoxyacetyl)-N-(4-methoxyphenyl)aminomalonate (942268-04-4) + 1-(4-bromophenyl)-2-propyn-1-one (54012-24-7) → (+/-)-(3R,4R)-3,5,5-tricarbomethoxy-4-[2-(4-bromophenyl)-2-oxoethyl]-1-(4-methoxyphenyl)pyrrolidin-2-one + (+/-)-(3R,4S)-3,5,5-tricarbomethoxy-4-[2-(4-bromophenyl)-2-oxoethyl]-1-(4-methoxyphenyl)pyrrolidin-2-one

Guidance literature:

With potassium tert-butylate; magnesium triflate; In dichloromethane; at 20 ℃; for 16h; Title compound not separated from byproducts.;

DOI:10.1021/ol070674f

upstream raw materials:

3-chloro-3-oxopropanoic acid methyl ester

dimethyl [N-(4-methoxyphenyl)aminomalonate]