(+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone

Base Information

• Chemical Name: (+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone
• CAS No.: 31892-95-2
• Molecular Formula: C₂₃H₂₂O₈
• Molecular Weight: 426.423
• Mol file: 31892-95-2.mol

Synonyms:(+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone

Chemical Property of (+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone

There total 1 articles about (+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-Methoxy-3,4-methylenedioxycinnamyl 3',4',5'-trimethoxyphenylpropiolate (15619-27-9) → (+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone (31892-95-2) + 1,2,3,4-dehydro-β-peltatin methyl ether (15656-72-1)

Guidance literature:

In N,N-dimethyl-formamide; at 145 ℃; for 1h; Yields of byproduct given;

DOI:10.1248/cpb.39.192

Reference yield: 99.0%

(+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid lactone (31892-95-2) → (+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid (133839-37-9)

Guidance literature:

With potassium hydroxide; In methanol; at 50 ℃; for 3h;

DOI:10.1248/cpb.39.192

upstream raw materials:

2-Methoxy-3,4-methylenedioxycinnamyl 3',4',5'-trimethoxyphenylpropiolate

Downstream raw materials:

(+/-)-2-Hydroxymethyl-8-methoxy-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid