2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester
CAS No.:872088-53-4
Molecular Formula:C₃₈H₄₄N₂O₈
Molecular Weight:656.776
Hs Code.:

2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

Synonyms:2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

There total 7 articles about 2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 872088-52-3
[4-(2-O-allyl-β-D-ribofuranosyl)imidazol-1-yl]methyl 2,2-dimethylpropiolate

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 872088-53-4
2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

Guidance literature:: With pyridine; dmap; triethylamine; at 20 ℃; for 19h;
DOI:10.1016/j.tet.2005.09.063

Reference yield:

: 872088-50-1
{4-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]imidazol-1-yl}methyl 2,2-dimethylpropiolate

: 872088-53-4
2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / PPh₃ / Pd₂(dba)3 / tetrahydrofuran / 15 h / Heating

2: 74 percent / TMEDA; aq. HF / acetonitrile / 3 h / 0 - 20 °C

3: 100 percent / pyridine; Et₃N; DMAP / 19 h / 20 °C

With pyridine; dmap; N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.tet.2005.09.063

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 872088-53-4
2,2-Dimethyl-propionic acid 4-{(2S,3R,4R,5R)-3-allyloxy-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-imidazol-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 3 h / 20 °C

1.2: 94 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 100 percent / cyclohexene / Pd(OH)2/C / ethanol / 3 h / Heating

3.1: 481 mg / pyridine / 4 h / 0 - 20 °C

4.1: 38 percent / PPh₃ / Pd₂(dba)3 / tetrahydrofuran / 15 h / Heating

5.1: 74 percent / TMEDA; aq. HF / acetonitrile / 3 h / 0 - 20 °C

6.1: 100 percent / pyridine; Et₃N; DMAP / 19 h / 20 °C

With pyridine; dmap; N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; sodium hydride; triethylamine; triphenylphosphine; cyclohexene; palladium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.tet.2005.09.063