4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

Base Information

Chemical Name:4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile
CAS No.:888228-05-5
Molecular Formula:C₁₇H₂₁F₄N₃
Molecular Weight:343.367
Hs Code.:

Synonyms:4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

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Chemical Property of 4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

Chemical Property:

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Technology Process of 4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

There total 3 articles about 4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 710982-52-8
1,1-dimethylethyl 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}(3-cyanopropyl)amino)piperidine-1-carboxylate

: 888228-05-5
4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 4-(3-cyano-propylamino)-piperidine-1-carboxylic acid tert-butyl ester

: 888228-05-5
4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1: Na(OAc)3BH / tetrahydrofuran

2: TFA / CH₂Cl₂

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 888228-05-5
4-[(4-fluoro-2-trifluoromethyl-benzyl)-piperidin-4-yl-amino]-butyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: Na(OAc)3BH / tetrahydrofuran

2: Na(OAc)3BH / tetrahydrofuran

3: TFA / CH₂Cl₂

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.02.008