C₅₈H₅₂ClN₅O₁₁

Base Information

Chemical Name:C₅₈H₅₂ClN₅O₁₁
CAS No.:218901-90-7
Molecular Formula:C₅₈H₅₂ClN₅O₁₁
Molecular Weight:1030.53
Hs Code.:

C<sub>58</sub>H<sub>52</sub>ClN<sub>5</sub>O<sub>11</sub>

Synonyms:C₅₈H₅₂ClN₅O₁₁

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Chemical Property of C₅₈H₅₂ClN₅O₁₁

Chemical Property:

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Technology Process of C₅₈H₅₂ClN₅O₁₁

There total 31 articles about C₅₈H₅₂ClN₅O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₀H₅₁ClF₃N₅O₁₂

: 218901-90-7
C₅₈H₅₂ClN₅O₁₁

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; methanol; at 0 ℃; Yield given;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P

Reference yield:

: 3-chloro-4-fluoro-5-nitro-benzaldehyde

: 218901-90-7
C₅₈H₅₂ClN₅O₁₁

Guidance literature:: Multi-step reaction with 28 steps

1: 1.) Sn(OTf)2, N-ethylpiperidine / 1.) THF, -78 deg C

2: DMAP / CH₂Cl₂

3: HCO₂H, H₂O₂ / H₂O

4: LiOOH / -5 °C

5: EDCI*HCl, HOBt / CH₂Cl₂; dimethylformamide / 0 °C

6: Li₂CO₃ / methanol / Ambient temperature

7: TFA, Me₂S / CH₂Cl₂ / 0 °C

8: EDCI*HCl, HOBt / tetrahydrofuran / 0 °C

9: TFA, Me₂S / CH₂Cl₂ / 0 °C

10: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

11: 65 percent / VOF₃, BF₃*Et₂O, AgBF₄ / trifluoroacetic acid; CH₂Cl₂ / 0 °C

12: NaHCO₃, H₂O / methanol / 144 h / Ambient temperature

13: HATU, HOAt, collidine / CH₂Cl₂; dimethylformamide / 16 h / -20 °C

14: 85 percent / HF*pyridine / tetrahydrofuran / 1 h / Ambient temperature

15: Na₂CO₃ / dimethylsulfoxide / 1.5 h / Ambient temperature

16: 1 h

17: Zn, HOAc / ethanol / 40 °C

18: NaNO₂, H₃PO₂, H₂O / Cu₂O / tetrahydrofuran / 1 h / 0 °C

19: 87 percent / Et₃N, HCO₂H / 2>*CH₂Cl₂ / dimethylformamide / 75 °C

20: Et₃N / tetrahydrofuran / Ambient temperature

21: TFA, Me₂S / CH₂Cl₂ / 0 °C

22: 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

23: 1.) AlBr₃, EtSH / 1.) CH₂Cl₂, 0 deg C, 2.) MeOH, 55 deg C, 24 h

24: Cs₂CO₃, Bu₄NI / dimethylformamide / 0 °C

25: LiSEt / tetrahydrofuran / 0 °C

26: Cs₂CO₃ / dimethylformamide / 0 °C

27: LDA / tetrahydrofuran / -78 °C

28: LiOH, H₂O / tetrahydrofuran; methanol / 0 °C

With 1-ethyl-piperidine; 2,6-dimethylpyridine; 2,3,5-trimethyl-pyridine; dmap; lithium hydroxide; silver tetrafluoroborate; tin(II) trifluoromethanesulfonate; formic acid; 1-hydroxy-7-aza-benzotriazole; aluminum tri-bromide; vanadium(V) oxytrifluoride; lithium hydroperoxide; dimethylsulfide; boron trifluoride diethyl etherate; water; dihydrogen peroxide; hypophosphorous acid; tetra-(n-butyl)ammonium iodide; lithium carbonate; sodium hydrogencarbonate; sodium carbonate; lithium thioethoxide; benzotriazol-1-ol; caesium carbonate; pyridine hydrogenfluoride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; ethanethiol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; lithium diisopropyl amide; sodium nitrite; copper(I) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P

Reference yield:

: 1026848-12-3
2-amino-2-(3,5-dimethoxy-phenyl)-N-methyl-acetamide

: 218901-90-7
C₅₈H₅₂ClN₅O₁₁

Guidance literature:: Multi-step reaction with 24 steps

1: EDCI*HCl, HOBt / CH₂Cl₂; dimethylformamide / 0 °C

2: Li₂CO₃ / methanol / Ambient temperature

3: TFA, Me₂S / CH₂Cl₂ / 0 °C

4: EDCI*HCl, HOBt / tetrahydrofuran / 0 °C

5: TFA, Me₂S / CH₂Cl₂ / 0 °C

6: 2,6-lutidine / CH₂Cl₂ / Ambient temperature

7: 65 percent / VOF₃, BF₃*Et₂O, AgBF₄ / trifluoroacetic acid; CH₂Cl₂ / 0 °C

8: NaHCO₃, H₂O / methanol / 144 h / Ambient temperature

9: HATU, HOAt, collidine / CH₂Cl₂; dimethylformamide / 16 h / -20 °C

10: 85 percent / HF*pyridine / tetrahydrofuran / 1 h / Ambient temperature

11: Na₂CO₃ / dimethylsulfoxide / 1.5 h / Ambient temperature

12: 1 h

13: Zn, HOAc / ethanol / 40 °C

14: NaNO₂, H₃PO₂, H₂O / Cu₂O / tetrahydrofuran / 1 h / 0 °C

15: 87 percent / Et₃N, HCO₂H / 2>*CH₂Cl₂ / dimethylformamide / 75 °C

16: Et₃N / tetrahydrofuran / Ambient temperature

17: TFA, Me₂S / CH₂Cl₂ / 0 °C

18: 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

19: 1.) AlBr₃, EtSH / 1.) CH₂Cl₂, 0 deg C, 2.) MeOH, 55 deg C, 24 h

20: Cs₂CO₃, Bu₄NI / dimethylformamide / 0 °C

21: LiSEt / tetrahydrofuran / 0 °C

22: Cs₂CO₃ / dimethylformamide / 0 °C

23: LDA / tetrahydrofuran / -78 °C

24: LiOH, H₂O / tetrahydrofuran; methanol / 0 °C

With 2,6-dimethylpyridine; 2,3,5-trimethyl-pyridine; lithium hydroxide; silver tetrafluoroborate; formic acid; 1-hydroxy-7-aza-benzotriazole; aluminum tri-bromide; vanadium(V) oxytrifluoride; dimethylsulfide; boron trifluoride diethyl etherate; water; hypophosphorous acid; tetra-(n-butyl)ammonium iodide; lithium carbonate; sodium hydrogencarbonate; sodium carbonate; lithium thioethoxide; benzotriazol-1-ol; caesium carbonate; pyridine hydrogenfluoride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; ethanethiol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; lithium diisopropyl amide; sodium nitrite; copper(I) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2700::AID-ANIE2700>3.0.CO;2-P