Technology Process of Methyl-<3-(S)-benzyl-8-aminomethyl-1,4-benzodiazepine-2-one>-acetate
There total 8 articles about Methyl-<3-(S)-benzyl-8-aminomethyl-1,4-benzodiazepine-2-one>-acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 1h;
under 2327.2 Torr;
DOI:10.1016/S0040-4020(01)90217-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) rt, 18 h
2: 1.) HCl(g), 2.) 1 N NaOH / 1.) ethyl acetate, 0 deg C, 1 h, 2.) MeOH, rt, overnight
3: 1.) NaH / 1.) DMF, rt, 30 min, 2.) rt, 1 h
4: 1.4 g / H2 / 10percent Pd-C / ethyl acetate / 1 h / 2327.2 Torr
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; isobutyl chloroformate;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1016/S0040-4020(01)90217-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) rt, 18 h
2: 1.) HCl(g), 2.) 1 N NaOH / 1.) ethyl acetate, 0 deg C, 1 h, 2.) MeOH, rt, overnight
3: 1.) NaH / 1.) DMF, rt, 30 min, 2.) rt, 1 h
4: 1.4 g / H2 / 10percent Pd-C / ethyl acetate / 1 h / 2327.2 Torr
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; isobutyl chloroformate;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1016/S0040-4020(01)90217-0
