4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

Base Information

Chemical Name:4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile
CAS No.:1050477-38-7
Molecular Formula:C₂₃H₂₁N₅O₃
Molecular Weight:415.451
Hs Code.:

Synonyms:4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

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Chemical Property of 4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

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Technology Process of 4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

There total 7 articles about 4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1050477-37-6
4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid

: 530-62-1
1,1'-carbonyldiimidazole

: 1050477-38-7
4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

Guidance literature:: In ethyl acetate;

Reference yield:

: 652997-57-4
3-methoxy-4-O-trifluoromethylsulfonylbenzonitrile

: 1050477-38-7
4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

2.1: sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride / tetrahydrofuran; water / 1 h / 20 - 30 °C

3.1: isopropyl alcohol / 72 h / Reflux; Inert atmosphere

4.1: 130 °C

4.2: 130 °C

5.1: water; sodium hydroxide / 1,2-dimethoxyethane / 20 °C

6.1: ethyl acetate / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 4421-08-3
3-methoxy-4-hydroxybenzonitrile

: 1050477-38-7
4-[5-ethoxy-3-(1H-imidazol-1-ylcarbonyl)-2-methyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 1 h / 20 - 25 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

3.1: sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride / tetrahydrofuran; water / 1 h / 20 - 30 °C

4.1: isopropyl alcohol / 72 h / Reflux; Inert atmosphere

5.1: 130 °C

5.2: 130 °C

6.1: water; sodium hydroxide / 1,2-dimethoxyethane / 20 °C

7.1: ethyl acetate / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;