(3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

Base Information

Chemical Name:(3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol
CAS No.:1350604-72-6
Molecular Formula:C₂₃H₂₀N₄O₂
Molecular Weight:384.437
Hs Code.:

Synonyms:(3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

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Chemical Property of (3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

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Technology Process of (3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

There total 4 articles about (3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1350607-38-3
2-[3-(3-chloropyrazin-2-yloxy)azetidin-1-yl]quinoline

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1350604-72-6
(3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

Guidance literature:: 2-[3-(3-chloropyrazin-2-yloxy)azetidin-1-yl]quinoline; [3-(hydroxymethyl)phenyl]boronic acid; With sodium carbonate; In 1,4-dioxane; water; for 0.0833333h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 64h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.10.013

Reference yield:

: 1340423-65-5
1-quinolin-2-yl-azetidin-3-ol

: 1350604-72-6
(3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

1.2: 90 °C

2.1: sodium carbonate / water; 1,4-dioxane / 0.08 h / Inert atmosphere

2.2: 64 h / 120 °C / Inert atmosphere

With sodium hydride; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling / 2.2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.10.013

Reference yield:

: 612-62-4
2-Chloroquinoline

: 1350604-72-6
(3-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 90 °C

3.1: sodium carbonate / water; 1,4-dioxane / 0.08 h / Inert atmosphere

3.2: 64 h / 120 °C / Inert atmosphere

With sodium hydride; sodium carbonate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.10.013