4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester
• CAS No.: 203584-42-3
• Molecular Formula: C₁₁H₁₆O₅
• Molecular Weight: 228.245
• Mol file: 203584-42-3.mol

Synonyms:4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester

Chemical Property of 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester

There total 3 articles about 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-(2-Bromo-allyl)-2-(3-oxo-propyl)-malonic acid dimethyl ester → 2-Allyl-2-(3-oxo-propyl)-malonic acid dimethyl ester + 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester (203584-42-3)

Guidance literature:

With triethyl borane; oxygen; tri-n-butyl-tin hydride; In toluene; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(97)10743-2

Reference yield: 17.0%

2-(2-Bromo-allyl)-2-(3-oxo-propyl)-malonic acid dimethyl ester → 2-Allyl-2-(3-oxo-propyl)-malonic acid dimethyl ester + (1R,4S)-6-Methylene-3-oxo-2-oxa-bicyclo[2.2.2]octane-4-carboxylic acid methyl ester + 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester (203584-42-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 2h; Heating;

DOI:10.1016/S0040-4039(97)10743-2

Reference yield:

2-(2-Bromo-allyl)-2-(3-oxo-propyl)-malonic acid dimethyl ester → (1R,4S)-6-Methylene-3-oxo-2-oxa-bicyclo[2.2.2]octane-4-carboxylic acid methyl ester + 3-(2-Oxo-ethyl)-cyclopentane-1,1-dicarboxylic acid dimethyl ester + 3-Formyl-cyclohexane-1,1-dicarboxylic acid dimethyl ester + 4-Hydroxy-3-methylene-cyclohexane-1,1-dicarboxylic acid dimethyl ester (203584-42-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 2h; Product distribution; Heating; product distribution dependent on stannane concentration in the reaction medium;

DOI:10.1016/S0040-4039(97)10743-2