1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol

Base Information

Chemical Name:1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol
CAS No.:85240-30-8
Molecular Formula:C₁₅H₁₉NO₅
Molecular Weight:293.32
Hs Code.:

Synonyms:1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol

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Chemical Property of 1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol

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Technology Process of 1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol

There total 9 articles about 1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 85281-05-6
N-(benzyloxycarbonyl)validamine

: 98-59-9
p-toluenesulfonyl chloride

: 85240-30-8
1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Reagent/catalyst;

Reference yield:

: 32780-32-8
validamine

: 85240-30-8
1L(1R)-(1,3,4/2)-<(benzyloxycarbonyl)amino>-6-methylene-1,2,3-cyclohexanetriol

Guidance literature:: Multi-step reaction with 6 steps

1: 31.8 g / H₂O; dioxane / 1.) 0-5 deg C, 1 h, 2.) room temp., 1 h

2: 5.1 g / pyridine / 15 h / Ambient temperature

3: 26.2 g / pyridine / 16 h / Ambient temperature

4: 16.9 g / sodium iodide / acetic anhydride / 0.5 h / 120 - 130 °C

5: 11.6 g / silver fluoride / pyridine / 3.5 h / 20 - 25 °C

6: 3.5 g / 5 M ammonium hydroxide / ethanol / 96 h / Ambient temperature

With ammonium hydroxide; silver fluoride; sodium iodide; In 1,4-dioxane; pyridine; ethanol; water; acetic anhydride;
DOI:10.1016/0008-6215(85)85122-3