3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide

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Chemical Name:3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide
CAS No.:1004763-62-5
Molecular Formula:C₂₃H₃₀N₄O₃S
Molecular Weight:442.582
Hs Code.:

Synonyms:3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide

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Chemical Property of 3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide

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Technology Process of 3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide

There total 2 articles about 3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1004764-54-8
methyl 3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanoate

: 1004763-62-5
3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide

Guidance literature:: With ammonia; In methanol; at 90 ℃; Sealed tube;

Reference yield:

: 1004764-50-4
2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

: 1004763-62-5
3-[2-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl]-3-oxopropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h

2: ammonia / methanol / 20 h / 90 °C

With ammonia; triethylamine; In methanol; dichloromethane;
DOI:10.1002/cmdc.201100248