methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate

Base Information

• Chemical Name: methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate
• CAS No.: 349662-90-4
• Molecular Formula: C₉H₁₁NO₂S₂
• Molecular Weight: 229.324
• Mol file: 349662-90-4.mol

Synonyms:methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate

Chemical Property of methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate

There total 1 articles about methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl (EZ)-2-cyano-3-cyclopropyl-2-butenoate → methyl 2-amino-4-cyclopropylthiophene-3-carboxylate (349662-85-7) + methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate (349662-90-4)

Guidance literature:

With sulfur; diethylamine; In methanol; at 35 ℃; for 42h;

DOI:10.1007/s007060170137

Reference yield: 91.0%

m-phenoxyphenylacetic acid chloride (86750-63-2) + methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate (349662-90-4) → 2-[2-(3-phenoxyphenyl)acetylamino]-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylic acid methyl ester

Guidance literature:

In 1,4-dioxane; at 98 ℃;

DOI:10.1021/jm0503493

Reference yield:

methyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-carboxylate (349662-90-4) → 5-hydroxy-6-(3-phenoxyphenyl)-3,4-dihydro-2H,8H-1,9-dithia-8-azafluoren-7-one

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / dioxane / 98 °C

2: 47 percent / KN(Si(CH₃)3)2 / tetrahydrofuran; toluene / -65 - 10 °C

With potassium hexamethylsilazane; In tetrahydrofuran; 1,4-dioxane; toluene;

DOI:10.1021/jm0503493